The main ingredient of Kupistha Rasayan is parad (mercury). This purified mercury is triturated with purified sulphur and other ingredients (Kajjali is prepared). These type of mixtures are put in kupi(bottle) and heated for twenty four to forty eight hours. These medicines are very potent and should be used in very minute dose. These medicaments have a very long shelf life and if used properly are effective as injections.